| Autor: |
Silva JC, Macedo LA, Souza GR, Oliveira-Junior RG, Lima-Saraiva SR, Lavor ÉM, Silva MG, Souza MT, Bonjardim LR, Quintans-Júnior LJ, Mendes RL, Almeida JR |
| Jazyk: |
angličtina |
| Zdroj: |
Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2016; Vol. 71 (7-8), pp. 209-14. |
| DOI: |
10.1515/znc-2015-5024 |
| Abstrakt: |
Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as "araticum" and "pinha da Caatinga". We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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