The Environmental Pollutant Tributyltin Chloride Disrupts the Hypothalamic-Pituitary-Adrenal Axis at Different Levels in Female Rats.

Autor:	Merlo E; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Podratz PL; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Sena GC; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., de Araújo JF; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Lima LC; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Alves IS; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Gama-de-Souza LN; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Pelição R; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Rodrigues LC; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Brandão PA; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Carneiro MT; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Pires RG; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Martins-Silva C; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Alarcon TA; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Miranda-Alves L; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Silva IV; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil., Graceli JB; Department of Morphology (E.M., P.L.P., G.C.S., J.F.P.d.A., I.S.S.A., L.N.G.-d.S., I.V.S., J.B.G.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Biophysics and Physiology (L.C.F.L.), Federal University of Minas Gerais, Vitória ES, 29040090 Brazil; Department of Physiological Sciences (R.P., L.C.M.R., R.G.W.P., C.M.-S., T.A.A.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Department of Chemistry (P.A.A.B., M.T.W.D.C.), Federal University of Espírito Santo, Vitória ES, 29040090 Brazil; Experimental Endocrinology Research Group (L.M.-A.), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil; and Postgraduate Program in Endocrinology (L.M.-A.), School of Medicine, Federal University of Rio de Janeiro, Vitória ES, 29040090 Brazil.
Jazyk:	angličtina
Zdroj:	Endocrinology [Endocrinology] 2016 Aug; Vol. 157 (8), pp. 2978-95. Date of Electronic Publication: 2016 Jun 07.
DOI:	10.1210/en.2015-1896
Abstrakt:	Tributyltin chloride (TBT) is an environmental contaminant that is used as a biocide in antifouling paints. TBT has been shown to induce endocrine-disrupting effects. However, studies evaluating the effects of TBT on the hypothalamus-pituitary-adrenal (HPA) axis are especially rare. The current study demonstrates that exposure to TBT is critically responsible for the improper function of the mammalian HPA axis as well as the development of abnormal morphophysiology in the pituitary and adrenal glands. Female rats were treated with TBT, and their HPA axis morphophysiology was assessed. High CRH and low ACTH expression and high plasma corticosterone levels were detected in TBT rats. In addition, TBT leads to an increased in the inducible nitric oxide synthase protein expression in the hypothalamus of TBT rats. Morphophysiological abnormalities, including increases in inflammation, a disrupted cellular redox balance, apoptosis, and collagen deposition in the pituitary and adrenal glands, were observed in TBT rats. Increases in adiposity and peroxisome proliferator-activated receptor-γ protein expression in the adrenal gland were observed in TBT rats. Together, these data provide in vivo evidence that TBT leads to functional dissociation between CRH, ACTH, and costicosterone, which could be associated an inflammation and increased of inducible nitric oxide synthase expression in hypothalamus. Thus, TBT exerts toxic effects at different levels on the HPA axis function.
Databáze:	MEDLINE
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