Role of Progenitor Cells in Liver Regeneration after Subtotal Resection.

Autor: El'chaninov AV; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Institute of Human Morphology, Moscow, Russia.; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Fatkhudinov TKh; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com.; Institute of Human Morphology, Moscow, Russia. fatkhudinov@gmail.com.; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. fatkhudinov@gmail.com., Kananykhina EY; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Institute of Human Morphology, Moscow, Russia., Usman NY; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Institute of Human Morphology, Moscow, Russia., Arutyunyan IV; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Institute of Human Morphology, Moscow, Russia., Makarov AV; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.; Institute of Human Morphology, Moscow, Russia.; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Bykov AV; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia., Bolshakova GV; Institute of Human Morphology, Moscow, Russia., Sukhikh GT; V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 May; Vol. 161 (1), pp. 155-61. Date of Electronic Publication: 2016 Jun 06.
DOI: 10.1007/s10517-016-3367-5
Abstrakt: In the liver of rats subjected to subtotal liver resection (80% organ weight), the expression of sox9 gene and SOX9 protein content increased and cells with hepatocyte morphology expressing SOX9 appeared; the proportion of cells expressing cytokeratin-19 also increased. Based on these data, we cannot completely exclude the involvement of resident progenitor cells and hepatocyte reprogramming in liver regeneration after subtotal resection, however, the contribution of these processes seems to be insignificant. The leading mechanism of liver mass recovery after subtotal resection is proliferation of hepatocytes.
Databáze: MEDLINE
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