The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats.

Autor: Larsen KE; Laboratorio de Biología y Ecotoxicología, FCV-UNCPBA, Tandil 7000, Argentina; Laboratorio de Farmacología, CIVETAN-CONICET, FCV-UNCPBA, Tandil 7000, Argentina., Lifschitz AL; Laboratorio de Farmacología, CIVETAN-CONICET, FCV-UNCPBA, Tandil 7000, Argentina., Lanusse CE; Laboratorio de Farmacología, CIVETAN-CONICET, FCV-UNCPBA, Tandil 7000, Argentina., Virkel GL; Laboratorio de Farmacología, CIVETAN-CONICET, FCV-UNCPBA, Tandil 7000, Argentina. Electronic address: gvirkel@vet.unicen.edu.ar.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2016 Jul; Vol. 45, pp. 41-4. Date of Electronic Publication: 2016 May 18.
DOI: 10.1016/j.etap.2016.05.012
Abstrakt: The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p<0.05) than those observed in kidney (females: 2.2-fold; males: 1.9-fold), liver (females: 6-fold; males: 6.9-fold) and plasma (females: 14.7-fold; males: 25.3-fold). Enzyme activities were higher in presence of 10mM GLP compared to those measured at an equimolar concentration of the potent AChE inhibitor dichlorvos (DDVP). Moreover, IC50s for GLP resulted between 6×10(4)- and 6.8×10(5)-fold higher than those observed for DDVP. In conclusion, GLP is a weak inhibitor of AChE in rats.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: