Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug.

Autor: Taracha E; Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego St., 02-957, Warsaw, Poland. taracha@ipin.edu.pl., Kaniuga E; Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego St., 02-957, Warsaw, Poland., Wyszogrodzka E; Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, 9 Sobieskiego St., 02-957, Warsaw, Poland., Płaźnik A; Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego St., 02-957, Warsaw, Poland.; Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26/28 Krakowskie Przedmieście St., 00-927, Warsaw, Poland., Stefański R; Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, 9 Sobieskiego St., 02-957, Warsaw, Poland., Chrapusta SJ; Department of Experimental Pharmacology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., 02-106, Warsaw, Poland.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2016 Jul; Vol. 233 (14), pp. 2827-40. Date of Electronic Publication: 2016 Jun 02.
DOI: 10.1007/s00213-016-4328-4
Abstrakt: Rationale: Our previous studies showed promise for using sensitization of the frequency-modulated 50-kHz vocalization response to amphetamine (AMPH) as an index of rat vulnerability to AMPH addiction.
Objective: This study aimed to test the utility of sensitizing frequency-modulated (FM) 50-kHz vocalization in the AMPH self-administration paradigm as well as the ability of N-acetylcysteine to prevent self-administration relapse.
Methods: Rats were subjected to the so-called two-injection protocol of sensitization (TIPS) using AMPH and were categorized as low-sensitized callers (LCTIPS) or high-sensitized callers (HCTIPS) based on the individual outcomes. Then, they were given 44 sessions of AMPH self-administration followed by a 17-session N-acetylcysteine-aided extinction course and a single session of AMPH-primed self-administration reinstatement.
Results: LCTIPS compared to HCTIPS rats showed no considerable difference in the FM 50-kHz vocalization rate during the self-administration training or extinction course, but they were considerably more likely to acquire AMPH self-administration and experience drug-induced reinstatement of this trait. Moreover, the LCTIPS rats were more likely than HCTIPS rats to have a markedly higher FM 50-kHz vocalization rate after AMPH reinstatement. N-acetylcysteine did not affect the course of self-administration extinction or the instrumental or FM 50-kHz vocalization responses to AMPH reinstatement.
Conclusions: There is no link between the FM 50-kHz vocalization and key characteristics of AMPH self-administration. Additionally, N-acetylcysteine does not help prevent AMPH self-administration relapse. However, there is a high predictive value for poor sensitization of the FM 50-kHz vocalization response to AMPH with respect to the acquisition and maintenance of self-administration of this psychostimulant.
Databáze: MEDLINE
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