Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats.

Autor: Hozayen WG; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. Walaahozayen@hotmail.com.; Biotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt. Walaahozayen@hotmail.com., El-Desouky MA; Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt., Soliman HA; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt., Ahmed RR; Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt., Khaliefa AK; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Jazyk: angličtina
Zdroj: BMC complementary and alternative medicine [BMC Complement Altern Med] 2016 Jun 02; Vol. 16, pp. 165. Date of Electronic Publication: 2016 Jun 02.
DOI: 10.1186/s12906-016-1140-y
Abstrakt: Background: Glucocorticoid-induced osteoporosis (GIO) is one of the serious side effects which have become the most common secondary osteoporosis. The purpose of this study is to evaluate the effect of aqueous extract of parsley, basil and chicory on glucocorticoid-induced osteoporosis in rats.
Methods: Fifty Female rats were divided into five groups and treated for 8 weeks as follow: group 1 served as control; group (2) subcutaneously injected with 0.1 mg/kg b. wt. dexamethasone dissolved in saline; group 3 received similar dose of dexamethasone together with aqueous parsley extract in a dose of 2 g/kg b. wt.; group 4 received similar dose of dexamethasone together with 400 mg/kg b. wt. aqueous basil extract and group 5 received similar dose of dexamethasone together with 100 mg/kg b. wt. aqueous chicory extract.
Results: The dexamethasone group showed a significant decrease in serum E2, Ca, P levels and significant decrease in total BMD, BMC and a significant increase in serum PTH, ALP and ACP. Bone TBARs was significantly increased while GSH, antioxidant enzymes were significantly decreased. These changes were attenuated by parsley, basil and chicory extracts in the group 3, 4 and 5 respectively.
Conclusion: Aqueous extracts of parsley, basil and chicory showed bone protection against glucocorticoid-induced in rats. From our results, we concluded that chicory has a potent protective effect more than parsley and basil due to containing flavonoids and inulin.
Databáze: MEDLINE
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