Longer duration of homelessness is associated with a lower likelihood of non-detectable plasma HIV-1 RNA viral load among people who use illicit drugs in a Canadian setting.

Autor: Loh J; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada., Kennedy MC; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada., Wood E; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada.; b Division of AIDS, Department of Medicine , University of British Columbia , Vancouver , Canada., Kerr T; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada.; b Division of AIDS, Department of Medicine , University of British Columbia , Vancouver , Canada., Marshall B; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada., Parashar S; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada., Montaner J; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada.; b Division of AIDS, Department of Medicine , University of British Columbia , Vancouver , Canada., Milloy MJ; a British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital , Vancouver , Canada.; b Division of AIDS, Department of Medicine , University of British Columbia , Vancouver , Canada.
Jazyk: angličtina
Zdroj: AIDS care [AIDS Care] 2016 Nov; Vol. 28 (11), pp. 1448-54. Date of Electronic Publication: 2016 Jun 01.
DOI: 10.1080/09540121.2016.1189498
Abstrakt: Homelessness is common among people who use drugs (PWUD) and, for those living with HIV/AIDS, an important contributor to sub-optimal HIV treatment outcomes. This study aims to investigate the relationship between the duration of homelessness and the likelihood of plasma HIV-1 RNA viral load (VL) non-detectability among a cohort of HIV-positive PWUD. We used data from the ACCESS study, a long-running prospective cohort study of HIV-positive PWUD linked to comprehensive HIV clinical records including systematic plasma HIV-1 RNA VL monitoring. We estimated the longitudinal relationship between the duration of homelessness and the likelihood of exhibiting a non-detectable VL (i.e., <500 copies/mL plasma) using generalized linear mixed-effects modelling. Between May 1996 and June 2014, 922 highly active antiretroviral therapy-exposed participants were recruited and contributed 8188 observations. Of these, 4800 (59%) were characterized by non-detectable VL. Participants reported they were homeless in 910 (11%) interviews (median: six months, interquartile range: 6-12 months). A longer duration of homelessness was associated with lower odds of VL non-detectability (adjusted odds ratio = 0.71 per six-month period of homelessness, 95% confidence interval: 0.60-0.83) after adjustment for age, ancestry, drug use patterns, engagement in addiction treatment, and other potential confounders. Longer durations of episodes of homelessness in this cohort of HIV-positive illicit drug users were associated with a lower likelihood of plasma VL non-detectability. Our findings suggest that interventions that seek to promptly house homeless individuals, such as Housing First approaches, might assist in maximizing the clinical and public health benefits of antiretroviral therapy among people living with HIV/AIDS.
Competing Interests: statement No potential conflict of interest was reported by the authors.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje