Male cytogenetic evaluation prior to assisted reproduction procedures performed in Mar del Plata, Argentina.

Autor:	Poli MN; Genetics Laboratory, Biology Department FCEyN, National University of Mar del Plata, Argentina.; CONICET - The National Scientific and Technical Research Council, Argentina.; Association of Human Genetics (AGHU) of Mar del Plata, Argentina., Miranda LA; Association of Human Genetics (AGHU) of Mar del Plata, Argentina., Gil ED; Association of Human Genetics (AGHU) of Mar del Plata, Argentina., Zanier GJ; Association of Human Genetics (AGHU) of Mar del Plata, Argentina., Iriarte PF; Genetics Laboratory, Biology Department FCEyN, National University of Mar del Plata, Argentina.; CONICET - The National Scientific and Technical Research Council, Argentina., Zanier JH; Association of Human Genetics (AGHU) of Mar del Plata, Argentina., Coco R; FECUNDITAS - Reproductive Medicine associated to Buenos Aires University, Argentina.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2016 May 01; Vol. 20 (2), pp. 62-5. Date of Electronic Publication: 2016 May 01.
DOI:	10.5935/1518-0557.20160015
Abstrakt:	Objective: This paper aimed to estimate the frequency of occurrence and the types of chromosomal abnormalities found in 141 infertile men with abnormal semen parameters. Methods: the frequency and type of chromosomal abnormalities were determined with male mitotic karyotype analysis from peripheral blood through chromosome banding techniques before assisted reproduction procedures. Results: In this series of 141 infertile men, 19 (13%) had chromosomal anomalies and 35 (25%) had polymorphic variants. The main chromosome abnormalities were reciprocal translocations and marker chromosomes in mosaic. Conclusions: These results stress the relevance of cytogenetic studies for infertile males as a diagnostic tool and a valuable input in genetic counseling.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu