Cell type specificity of neurovascular coupling in cerebral cortex.

Autor: Uhlirova H; Department of Radiology, University of California, San Diego, La Jolla, United States., Kılıç K; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Tian P; Department of Neurosciences, University of California, San Diego, La Jolla, United States.; Department of Physics, John Carroll University, University Heights, United States., Thunemann M; Department of Radiology, University of California, San Diego, La Jolla, United States., Desjardins M; Department of Radiology, University of California, San Diego, La Jolla, United States., Saisan PA; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Sakadžić S; Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, United States., Ness TV; Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Ås, Norway., Mateo C; Department of Physics, University of California, San Diego, La Jolla, United States., Cheng Q; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Weldy KL; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Razoux F; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Vandenberghe M; Department of Radiology, University of California, San Diego, La Jolla, United States.; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway., Cremonesi JA; Biology Undergraduate Program, University of California, San Diego, La Jolla, United States., Ferri CG; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Nizar K; Neurosciences Graduate Program, University of California, San Diego, La Jolla, United States., Sridhar VB; Department of Bioengineering, University of California, San Diego, La Jolla, United States., Steed TC; Neurosciences Graduate Program, University of California, San Diego, La Jolla, United States., Abashin M; Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, United States., Fainman Y; Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, United States., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway., Andreassen OA; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway., Silva GA; Department of Bioengineering, University of California, San Diego, La Jolla, United States.; Department of Ophthalmology, University of California, San Diego, La Jolla, United States., Boas DA; Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, United States., Kleinfeld D; Department of Physics, University of California, San Diego, La Jolla, United States.; Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, United States.; Section of Neurobiology, University of California, San Diego, La Jolla, United States., Buxton RB; Department of Radiology, University of California, San Diego, La Jolla, United States., Einevoll GT; Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Ås, Norway.; Department of Physics, University of Oslo, Oslo, Norway., Dale AM; Department of Radiology, University of California, San Diego, La Jolla, United States.; Department of Neurosciences, University of California, San Diego, La Jolla, United States., Devor A; Department of Radiology, University of California, San Diego, La Jolla, United States.; Department of Neurosciences, University of California, San Diego, La Jolla, United States.; Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, United States.
Jazyk: angličtina
Zdroj: ELife [Elife] 2016 May 31; Vol. 5. Date of Electronic Publication: 2016 May 31.
DOI: 10.7554/eLife.14315
Abstrakt: Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.
Databáze: MEDLINE