Ethnicity is an independent predictor of IVF-ICSI outcome: a study of 5,549 cycles in Spain and India.

Autor: Patel AP; a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and., Patel JA; a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and., Cruz M; b Department of Reproductive Medicine , IVI (Instituto Valenciano de Infertilidad) , Madrid , Spain., Gupte-Shah A; a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and., Garcia Velasco JA; b Department of Reproductive Medicine , IVI (Instituto Valenciano de Infertilidad) , Madrid , Spain., Banker MR; a Department of Reproductive Medicine , NIF (Nova IVI Fertility) Clinic , Ahmedabad , India and.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2016 Oct; Vol. 32 (10), pp. 819-822. Date of Electronic Publication: 2016 May 31.
DOI: 10.1080/09513590.2016.1188377
Abstrakt: Aim: To determine the role of ethnicity on IVF/ICSI outcomes between Indian and white Caucasian women.
Settings and Design: Retrospective cohort study.
Materials and Methods: White Caucasian and Indian women undergoing IVF/ICSI treatment cycles. Total 5549 self, non-donor, fresh IVF cycles conducted from January 2014 to March 2015, out of which, 4227 were white Caucasian and 1322 were Indian. Data were collected on baseline characteristics, IVF cycle parameters and outcomes. Ongoing pregnancy rate (OPR) was measured as main outcome.
Results: Indian women differed significantly from white Caucasian women in baseline characteristics like age (30.6 ± 0.2 versus 37.6 ± 0.1 years; p < 0.001), BMI (22.3 ± 0.2 versus 26.6 ± 1.0 kg/m 2 ; p < 0.05), duration of infertility (6.9 ± 3.0 versus 2.5 ± 0.1 years; p < 0.001) and antral follicle count (AFC) (8.9 ± 0.4 versus 7.5 ± 0.2; p < 0.001). Indian women had lower implantation rate (30.1% versus 39.6%: p < 0.001) and OPR (35.1% versus 41.7%: p < 0.001) compared with white Caucasian women. Regression analysis proved independent effect of ethnicity on OPR (OR 0.944; 95% CI 0.928-0.961: p < 0.001) Conclusions: OPR was significantly lower among Indian ethnic group following IVF/ICSI suggest that ethnicity, like age, is a major and an independent predictor of IVF outcome.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje