Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits.

Autor: Akyol S; Department of Medical Biology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey. Electronic address: sumeyyaak@gmail.com., Yuksel S; Department of Child Development, School of Health, Turgut Ozal University, Ankara, Turkey., Pehlivan S; Ankara Regional Office of Council of Forensic Medicine, Morgue Department, Ankara, Turkey., Erdemli HK; Department of Biochemistry Laboratory, Corum Training and Research Hospital, Corum, Turkey., Gulec MA; Department of Medical Biochemistry, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey., Adam B; Department of Biochemistry & Molecular Medicine, University of California, Davis, California, United States., Akyol O; Department of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Medical hypotheses [Med Hypotheses] 2016 Jul; Vol. 92, pp. 3-6. Date of Electronic Publication: 2016 Apr 09.
DOI: 10.1016/j.mehy.2016.04.015
Abstrakt: Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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