Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection.

Autor: Meyers NL; Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States., Fontaine KA; Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States., Kumar GR; Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States., Ott M; Gladstone Institutes, University of California San Francisco, 1650 Owens Street, San Francisco, CA 94941, United States. Electronic address: Mott@gladstone.ucsf.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2016 Aug; Vol. 41, pp. 117-24. Date of Electronic Publication: 2016 May 27.
DOI: 10.1016/j.ceb.2016.05.003
Abstrakt: Hepatitis C virus (HCV) is a major cause of liver disease worldwide. To establish and maintain chronic infection, HCV extensively rearranges cellular organelles to generate distinct compartments for viral RNA replication and virion assembly. Here, we review our current knowledge of how HCV proliferates and remodels ER-derived membranes while preserving and expanding associated lipid droplets during viral infection. Unraveling the molecular mechanisms responsible for HCV-induced membrane reorganization will enhance our understanding of the HCV life-cycle, the associated liver pathology, and the biology of the ER:lipid droplet interface in general.
(Copyright © 2016. Published by Elsevier Ltd.)
Databáze: MEDLINE
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