Maternal food restriction in rats of the F 0 generation increases retroperitoneal fat, the number and size of adipocytes and induces periventricular astrogliosis in female F 1 and male F 2 generations.

Autor: Joaquim AO; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Coelho CP; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Motta PD; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Felício LF; Department of Pathology, School of Veterinary Medicine, University of São Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87, Sao Paulo, SP, 05508-270, Brazil., Bondan EF; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Teodorov E; Mathematics, Computing and Cognition Center, Federal University of ABC, Av. dos Estados, 5001, Santo André, SP, 09210-971, Brazil., Martins MFM; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Kirsten TB; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Bonamin LV; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil., Bernardi MM; Environmental and Experimental Pathology, Paulista University, UNIP, Rua Dr Bacelar, 1212, São Paulo, SP, 04026-002, Brazil.
Jazyk: angličtina
Zdroj: Reproduction, fertility, and development [Reprod Fertil Dev] 2017 Jul; Vol. 29 (7), pp. 1340-1348.
DOI: 10.1071/RD15309
Abstrakt: The present study investigated whether male offspring (F 2 generation) from female rats (F 1 generation) whose mothers (F 0 generation) were food restricted during gestation inherit a phenotypic transgenerational tendency towards being overweight and obese in the juvenile period, in the absence of food restriction in the F 1 /F 2 generations. Dams of the F 0 generation were 40% food restricted during pregnancy. Bodyweight, the number and size of larger and small hypodermal adipocytes (HAs), total retroperitoneal fat (RPF) weight and the expression of glial fibrillary acidic protein (GFAP) in periventricular hypothalamic astrocytes (PHAs), as determined by immunohistochemistry, were evaluated in both generations. In the female F 1 generation, there was low bodyweight gain only during the juvenile period (30-65 days of age), a decrease in the size of small adipocytes, an increase in the number of small adipocytes, an increase in RPF weight and an increase in GFAP expression in PHAs at 90-95 days of age. In males of the F 2 generation at 50 days of age, there was increased bodyweight and RPF weight, and a small number of adipocytes and GFAP expression in PHAs. These data indicate that the phenotypic transgenerational tendency towards being overweight and obese was observed in females (F 1 ) from mothers (F 0 ) that were prenatally food restricted was transmitted to their male offspring.
Databáze: MEDLINE
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