Diagnostic value of occult fecal blood testing for colorectal cancer screening.

Autor:	Chen K; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Jiao DA; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Zheng S; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Zhou L; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Yu H; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Yuan YC; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Yao KY; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Ma XY; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China., Zhang Y; Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 1997 Sep 15; Vol. 3 (3), pp. 166-8.
DOI:	10.3748/wjg.v3.i3.166
Abstrakt:	Aim: To evaluate the diagnostic value of occult fecal blood testing in mass colorectal cancer screening. Methods: A reverse passive hemagglutination reaction fecal occult blood test (RPHA-FOBT) and colorectal cancer risk factor quantitative method were used as preliminary screening for colorectal cancer. A 60-cm fiber optic colonoscopy was used to validate the preliminary screen and was used to detect colorectal cancer in a community of 75813 subjects. Results: Compared to the 60-cm fiber optic colonoscopy as a standard reference, FOBT has a sensitivity of 41.9%, specificity of 95.8%, Youden's index of 0.38, and positive predictive value of 0.68%. These results increased with subject age from the first detection. A 3-year follow up in the target mass showed that all new cases had initially been FOBT-negative. Conclusion: The value of FOBT as an indicator of colorectal cancer in mass screening is limited.
Databáze:	MEDLINE
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