| Autor: |
Scamp RJ; Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States., Jirak JG; Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States., Dolan NS; Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States., Guzei IA; Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States., Schomaker JM; Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States. |
| Abstrakt: |
The discovery of transition metal complexes capable of promoting general, catalyst-controlled and selective carbon-hydrogen (C-H) bond amination of activated secondary C-H bonds over tertiary alkyl C(sp(3))-H bonds is challenging, as substrate control often dominates when reactive nitrene intermediates are involved. In this letter, we report the design of a new silver complex, [(Py5Me2)AgOTf]2, that displays general and good-to-excellent selectivity for nitrene insertion into propargylic, benzylic, and allylic C-H bonds over tertiary alkyl C(sp(3))-H bonds. |
