Ebola Virus Disease in Pregnancy: Clinical, Histopathologic, and Immunohistochemical Findings.

Autor:	Muehlenbachs A; Infectious Diseases Pathology Branch., de la Rosa Vázquez O; Médecins Sans Frontières, Barcelona, Spain., Bausch DG; Viral Special Pathogens Branch., Schafer IJ; Viral Special Pathogens Branch., Paddock CD; Rickettsial Zoonoses Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia., Nyakio JP; Médecins Sans Frontières., Lame P; Médecins Sans Frontières., Bergeron E; Viral Special Pathogens Branch., McCollum AM; Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology., Goldsmith CS; Infectious Diseases Pathology Branch., Bollweg BC; Infectious Diseases Pathology Branch., Prieto MA; Médecins Sans Frontières, Barcelona, Spain., Lushima RS; Ministry of Health, Kinshasa, Democratic Republic of the Congo., Ilunga BK; Ministry of Health, Kinshasa, Democratic Republic of the Congo., Nichol ST; Viral Special Pathogens Branch., Shieh WJ; Infectious Diseases Pathology Branch., Ströher U; Viral Special Pathogens Branch., Rollin PE; Viral Special Pathogens Branch., Zaki SR; Infectious Diseases Pathology Branch.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2017 Jan 01; Vol. 215 (1), pp. 64-69. Date of Electronic Publication: 2016 May 25.
DOI:	10.1093/infdis/jiw206
Abstrakt:	Here we describe clinicopathologic features of Ebola virus disease in pregnancy. One woman infected with Sudan virus in Gulu, Uganda, in 2000 had a stillbirth and survived, and another woman infected with Bundibugyo virus had a live birth with maternal and infant death in Isiro, the Democratic Republic of the Congo in 2012. Ebolavirus antigen was seen in the syncytiotrophoblast and placental maternal mononuclear cells by immunohistochemical analysis, and no antigen was seen in fetal placental stromal cells or fetal organs. In the Gulu case, ebolavirus antigen localized to malarial parasite pigment-laden macrophages. These data suggest that trophoblast infection may be a mechanism of transplacental ebolavirus transmission. (Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.)
Databáze:	MEDLINE
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