Chair/bedside diagnosis of oral and respiratory tract infections, and identification of antibiotic resistances for personalised monitoring and treatment.

Autor:	Mitsakakis K; Hahn-Schickard, Freiburg, Germany., Stumpf F; Hahn-Schickard, Freiburg, Germany., Strohmeier O; Hahn-Schickard, Freiburg, Germany., Klein V; Hahn-Schickard, Freiburg, Germany., Mark D; Hahn-Schickard, Freiburg, Germany., Von Stetten F; Hahn-Schickard, Freiburg, Germany., Peham JR; Health & Environment Department, AIT Austrian Institute of Technology, Vienna Austria., Herz C; Health & Environment Department, AIT Austrian Institute of Technology, Vienna Austria., Tawakoli PN; Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland., Wegehaupt F; Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland., Attin T; Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland., Bostanci N; Division of Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland., Bao K; Division of Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland., Belibasakis GN; Division of Oral Microbiology and Immunology, Institute of Oral Biology, Center of Dental Medicine, University of Zurich, Zurich, Switzerland., Hays JP; Erasmus University Medical Centre, Rotterdam, The Netherlands., Elshout G; Erasmus University Medical Centre, Rotterdam, The Netherlands., Huisman RC; Erasmus University Medical Centre, Rotterdam, The Netherlands., Klein S; Erasmus University Medical Centre, Rotterdam, The Netherlands., Stubbs AP; Erasmus University Medical Centre, Rotterdam, The Netherlands., Doms L; Askion GmbH, Gera, Germany., Wolf A; Askion GmbH, Gera, Germany., Rusu V; MagnaMedics Diagnostics BV, Geleen, The Netherlands., Goethel S; MagnaMedics Diagnostics BV, Geleen, The Netherlands., Binsl T; ClinicaGeno Ltd, London, United Kingdom., Michie A; ClinicaGeno Ltd, London, United Kingdom., Jancovicova J; BioVendor - Laboratorni medicina a.s., Brno, Czech Republic., Kolar V; BioVendor - Laboratorni medicina a.s., Brno, Czech Republic., Kostka M; BioVendor - Laboratorni medicina a.s., Brno, Czech Republic., Smutny J; BioVendor - Laboratorni medicina a.s., Brno, Czech Republic., Karpisek M; BioVendor - Laboratorni medicina a.s., Brno, Czech Republic., Estephan C; Sparks & Co, Paris, France., Cocaud C; Sparks & Co, Paris, France., Zengerle R; Hahn-Schickard, Freiburg, Germany.
Jazyk:	angličtina
Zdroj:	Studies in health technology and informatics [Stud Health Technol Inform] 2016; Vol. 224, pp. 61-6.
Abstrakt:	Global healthcare systems are struggling with the enormous burden associated with infectious diseases, as well as the incessant rise of antimicrobial resistance. In order to adequately address these issues, there is an urgent need for rapid and accurate infectious disease diagnostics. The H2020 project DIAGORAS aims at diagnosing oral and respiratory tract infections using a fully integrated, automated and user-friendly platform for physicians' offices, schools, elderly care units, community settings, etc. Oral diseases (periodontitis, dental caries) will be detected via multiplexed, quantitative analysis of salivary markers (bacterial DNA and host response proteins) for early prevention and personalised monitoring. Respiratory Tract Infections will be diagnosed by means of DNA/RNA differentiation so as to identify their bacterial or viral nature. Together with antibiotic resistance screening on the same platform, a more efficient treatment management is expected at the point-of-care. At the heart of DIAGORAS lies a centrifugal microfluidic platform (LabDisk and associated processing device) integrating all components and assays for a fully automated analysis. The project involves an interface with a clinical algorithm for the comprehensive presentation of results to end-users, thereby increasing the platform's clinical utility. DIAGORAS' performance will be validated at clinical settings and compared with gold standards.
Databáze:	MEDLINE
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