Dual behavior of N-acetylcysteine during ethanol-induced oxidative stress in embryonic chick brains.
Autor: | Bauer AK; a Lake Erie College of Osteopathic Medicine , Erie , PA 16509 , USA., Fitzgerald M; b Michigan State University College of Human Medicine , East Lansing , USA., Ladzinski AT; c Midwestern University College of Osteopathic Medicine , Downers Grove , IL 60515 , USA., Lenhart Sherman S; d School of Dentistry , University of Michigan , Ann Arbor , USA., Maddock BH; e College of Medicine , University of Rochester , NY , USA., Norr ZM; f Biology Department , Hillsdale College , MI 49242 , USA., Miller RR Jr; f Biology Department , Hillsdale College , MI 49242 , USA. |
---|---|
Jazyk: | angličtina |
Zdroj: | Nutritional neuroscience [Nutr Neurosci] 2017 Oct; Vol. 20 (8), pp. 478-488. Date of Electronic Publication: 2016 May 24. |
DOI: | 10.1080/1028415X.2016.1185261 |
Abstrakt: | Objectives: Ethanol (EtOH) causes oxidative stress in embryos. Because N-acetylcysteine (NAC) failures and successes in ameliorating EtOH-induced oxidative stress have been reported, the objective was to determine if exogenous NAC ameliorated EtOH-induced oxidative stress within embryonic chick brains. Methods: Control eggs were injected with approximately 25 µl of water on day 0, 1, and 2 of development (E Results: EtOH (3 mmol/kg egg), medium NAC (747 µmol/kg egg), and EtOH and medium NAC promoted oxidative stress. These treatments caused decreased brain membrane long-chain PUFAs; increased LPO levels; decreased GSH levels and GSH/GSSG levels; and decreased Se-dependent GPx activities. High NAC dosages (1000 µmol/kg egg) attenuated EtOH-induced oxidative stress within EtOH and high NAC-treated chick brains. Discussion: Exogenous EtOH and/or medium NAC propagated oxidative stress. Meanwhile, high NAC ameliorated EtOH-induced oxidative stress. |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |