In Vivo Efficacy and Tolerability of Artesunate-Azithromycin for the Treatment of Falciparum Malaria in Vietnam.

Autor:	Phong NC; Malaria Department, Military Institute of Preventive Medicine, Hanoi, Vietnam., Quang HH; Malaria Department, Institute of Malariology, Parasitology and Entomology, Quy Nhon, Vietnam., Thanh NX; Malaria Department, Military Institute of Preventive Medicine, Hanoi, Vietnam., Trung TN; Malaria Department, Institute of Malariology, Parasitology and Entomology, Quy Nhon, Vietnam., Dai B; Malaria Department, Military Institute of Preventive Medicine, Hanoi, Vietnam., Shanks GD; Department of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia., Chavchich M; Department of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia., Edstein MD; Department of Drug Evaluation, Australian Army Malaria Institute, Brisbane, Australia. mike.edstein@defence.gov.au.
Jazyk:	angličtina
Zdroj:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2016 Jul 06; Vol. 95 (1), pp. 164-7. Date of Electronic Publication: 2016 May 23.
DOI:	10.4269/ajtmh.16-0144
Abstrakt:	Safe and effective antimalarial drugs are required for the treatment of pregnant women. We report a 3-day regimen of artesunate (4 mg/kg/day)-azithromycin (25 mg/kg/day) (ASAZ) to be efficacious (polymerase chain reaction-corrected cure rate of 96.7%) and well tolerated in the treatment of Plasmodium falciparum malaria in children (N = 11) and adults (N = 19), in Vietnam in 2010. In comparison, the cure rate for artesunate (4 mg/kg on day 0, 2 mg/kg on days 1-6) was 90.0% in children (N = 7) and adults (N = 23). Because azithromycin is considered safe in pregnancy, our findings provide further evidence that ASAZ should be evaluated for the treatment of pregnant women with malaria. (© The American Society of Tropical Medicine and Hygiene.)
Databáze:	MEDLINE
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