Child Stunting is Associated with Low Circulating Essential Amino Acids.

Autor:	Semba RD; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rdsemba@jhmi.edu., Shardell M; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Sakr Ashour FA; Department of Nutrition & Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD, USA., Moaddel R; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Trehan I; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi., Maleta KM; School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi., Ordiz MI; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA., Kraemer K; Sight and Life, Basel, Switzerland; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Khadeer MA; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Ferrucci L; National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Manary MJ; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi.
Jazyk:	angličtina
Zdroj:	EBioMedicine [EBioMedicine] 2016 Apr; Vol. 6, pp. 246-252. Date of Electronic Publication: 2016 Feb 19.
DOI:	10.1016/j.ebiom.2016.02.030
Abstrakt:	Background: Stunting affects about one-quarter of children under five worldwide. The pathogenesis of stunting is poorly understood. Nutritional interventions have had only modest effects in reducing stunting. We hypothesized that insufficiency in essential amino acids may be limiting the linear growth of children. Methods: We used a targeted metabolomics approach to measure serum amino acids, glycerophospholipids, sphingolipids, and other metabolites using liquid chromatography-tandem mass spectrometry in 313 children, aged 12-59months, from rural Malawi. Children underwent anthropometry. Findings: Sixty-two percent of the children were stunted. Children with stunting had lower serum concentrations of all nine essential amino acids (tryptophan, isoleucine, leucine, valine, methionine, threonine, histidine, phenylalanine, lysine) compared with nonstunted children (p<0.01). In addition, stunted children had significantly lower serum concentrations of conditionally essential amino acids (arginine, glycine, glutamine), non-essential amino acids (asparagine, glutamate, serine), and six different sphingolipids compared with nonstunted children. Stunting was also associated with alterations in serum glycerophospholipid concentrations. Interpretation: Our findings support the idea that children with a high risk of stunting may not be receiving an adequate dietary intake of essential amino acids and choline, an essential nutrient for the synthesis of sphingolipids and glycerophospholipids. (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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