Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance.
| Autor: | Molin Netto BD; aPost Graduate Program of Nutrition, Universidade Federal de São Paulo - Escola Paulista de Medicina - UNIFESP-EPM, São Paulo, São Paulo bBariatric Surgery Service cBiochemistry Section, Hospital de Clínicas dDepartment of Nutrition eGraduation in Nutrition, Federal University of Paraná - UFPR, Curitiba, Paraná, Brazil fDepartment of Food Science and Nutrition, University of Minnesota - Twin Cities, Minneapolis, Minnesota, USA., Earthman CP, Cravo Bettini S, Grotti Clemente AP, Landi Masquio DC, Farias G, Boritza K, da Silva LG, von der Heyde ME, Dâmaso AR |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2016 Sep; Vol. 28 (9), pp. 1050-5. |
| DOI: | 10.1097/MEG.0000000000000665 |
| Abstrakt: | Introduction: Body weight varies depending on the prevailing direction of environmental pressures; however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods: The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results: The BMI decreased from 44.3±6.4 to 31.7±5.7 kg/m (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2±25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator α-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion: In the present investigation, it was found that there is a relationship between α-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|