Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B.

Autor:	Dong CF; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Xiao J; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Shan LB; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Li HY; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Xiong YJ; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Yang GL; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Liu J; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Yao SM; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Li SX; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Le XH; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Yuan J; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Zhou BP; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Tipoe GL; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China., Liu YX; Chang-Feng Dong, Han-Ying Li, Division of Ultrasound, Shenzhen Third People's Hospital, Shenzhen 518112, China.
Jazyk:	angličtina
Zdroj:	World journal of hepatology [World J Hepatol] 2016 May 18; Vol. 8 (14), pp. 616-24.
DOI:	10.4254/wjh.v8.i14.616
Abstrakt:	Aim: To investigate the combined diagnostic accuracy of acoustic radiation force impulse (ARFI), aspartate aminotransferase to platelet ratio index (APRI) and Forns index for a non-invasive assessment of liver fibrosis in patients with chronic hepatitis B (CHB). Methods: In this prospective study, 206 patients had CHB with liver fibrosis stages F0-F4 classified by METAVIR and 40 were healthy volunteers were measured by ARFI, APRI and Forns index separately or combined as indicated. Results: ARFI, APRI or Forns index demonstrated a significant correlation with the histological stage (all P < 0.001). According to the AUROC of ARFI and APRI for evaluating fibrotic stages more than F2, ARFI showed an enhanced diagnostic accuracy than APRI (P < 0.05). The combined measurement of ARFI and APRI exhibited better accuracy than ARFI alone when evaluating ≥ F2 fibrotic stage (Z = 2.77, P = 0.006). Combination of ARFI, APRI and Forns index did not obviously improve the diagnostic accuracy compared to the combination of ARFI and APRI (Z = 0.958, P = 0.338). Conclusion: ARFI + APRI showed enhanced diagnostic accuracy than ARFI or APRI alone for significant liver fibrosis and ARFI + APRI + Forns index shows the same effect with ARFI + APRI.
Databáze:	MEDLINE
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