Central arterial stiffness is associated with systemic inflammation among Asians with type 2 diabetes.

Autor:	Zhang X; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Liu JJ; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Fang Sum C; Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Republic of Singapore Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Ying YL; Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Tavintharan S; Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Republic of Singapore Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Ng XW; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Su C; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Low S; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Republic of Singapore., Lee SB; National Healthcare Group Polyclinics, Singapore, Republic of Singapore., Tang WE; National Healthcare Group Polyclinics, Singapore, Republic of Singapore., Lim SC; Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Republic of Singapore Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore lim.su.chi@alexandrahealth.com.sg.
Jazyk:	angličtina
Zdroj:	Diabetes & vascular disease research [Diab Vasc Dis Res] 2016 Jul; Vol. 13 (4), pp. 303-6. Date of Electronic Publication: 2016 Apr 18.
DOI:	10.1177/1479164116635021
Abstrakt:	Objective: To examine the relationship between inflammation and central arterial stiffness in a type 2 diabetes Asian cohort. Method: Central arterial stiffness was estimated by carotid-femoral pulse wave velocity and augmentation index. Linear regression model was used to evaluate the association of high-sensitivity C-reactive protein and soluble receptor for advanced glycation end products with pulse wave velocity and augmentation index. High-sensitivity C-reactive protein was analysed as a continuous variable and categories (<1, 1-3, and >3 mg/L). Results: There is no association between high-sensitivity C-reactive protein and pulse wave velocity. Augmentation index increased with high-sensitivity C-reactive protein as a continuous variable (β = 0.328, p = 0.049) and categories (β = 1.474, p = 0.008 for high-sensitivity C-reactive protein: 1-3 mg/L and β = 1.323, p = 0.019 for high-sensitivity C-reactive protein: >3 mg/L) after multivariable adjustment. No association was observed between augmentation index and soluble receptor for advanced glycation end products. Each unit increase in natural log-transformed soluble receptor for advanced glycation end products was associated with 0.328 m/s decrease in pulse wave velocity after multivariable adjustment (p = 0.007). Conclusion: Elevated high-sensitivity C-reactive protein and decreased soluble receptor for advanced glycation end products are associated with augmentation index and pulse wave velocity, respectively, suggesting the potential role of systemic inflammation in the pathogenesis of central arterial stiffness in type 2 diabetes. (© The Author(s) 2016.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu