Identification of proliferative progenitors associated with prominent postnatal growth of the pons.

Autor:	Lindquist RA; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Medical Scientist Training Program, University of California-San Francisco, San Francisco, California 94143, USA.; Neuroscience Graduate Program, University of California-San Francisco, San Francisco, California 94143, USA., Guinto CD; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94143, USA., Rodas-Rodriguez JL; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94143, USA., Fuentealba LC; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94143, USA., Tate MC; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94143, USA., Rowitch DH; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Department of Pediatrics, University of California-San Francisco, San Francisco, California 94143, USA., Alvarez-Buylla A; Eli &Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California-San Francisco, San Francisco, California 94143, USA.; Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94143, USA.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2016 May 18; Vol. 7, pp. 11628. Date of Electronic Publication: 2016 May 18.
DOI:	10.1038/ncomms11628
Abstrakt:	The pons controls crucial sensorimotor and autonomic functions. In humans, it grows sixfold postnatally and is a site of paediatric gliomas; however, the mechanisms of pontine growth remain poorly understood. We show that the murine pons quadruples in volume postnatally; growth is fastest during postnatal days 0-4 (P0-P4), preceding most myelination. We identify three postnatal proliferative compartments: ventricular, midline and parenchymal. We find no evidence of postnatal neurogenesis in the pons, but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to 18-fold postnatally, and are derived mostly from the parenchyma. Nearly all parenchymal progenitors at P4 are Sox2(+)Olig2(+), but by P8 a Sox2(-) subpopulation emerges, suggesting a lineage progression from Sox2(+) 'early' to Sox2(-) 'late' oligodendrocyte progenitor. Fate mapping reveals that >90% of adult oligodendrocytes derive from P2-P3 Sox2(+) progenitors. These results demonstrate the importance of postnatal Sox2(+)Olig2(+) progenitors in pontine growth and oligodendrogenesis.
Databáze:	MEDLINE
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