Efficacy of contrast-enhanced harmonic endoscopic ultrasonography in the diagnosis of pancreatic ductal carcinoma.

Autor: Uekitani T; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan., Kaino S; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan., Harima H; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan., Suenaga S; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan., Sen-Yo M; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan., Sakaida I; Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Japan.
Jazyk: angličtina
Zdroj: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association [Saudi J Gastroenterol] 2016 May-Jun; Vol. 22 (3), pp. 198-202.
DOI: 10.4103/1319-3767.182457
Abstrakt: Background/aims: Distinguishing pancreatic ductal carcinoma (DC) from other pancreatic masses remains challenging. This study aims at evaluating the efficacy of contrast-enhanced harmonic endoscopic ultrasonography (CEH-EUS) in the diagnosis of DC.
Patients and Methods: Forty-nine patients with solid pancreatic mass lesions underwent CEH-EUS. EUS (B-mode) was used to evaluate the inner echoes, distributions, and borders of the masses. The vascular patterns of the masses were evaluated with CEH-EUS at 30-50 s (early phase) and 70-90 s (late phase) after the administration of Sonazoid®.
Results: The final diagnoses included DCs (37), mass-forming pancreatitis (6), endocrine neoplasms (3), a solid pseudopapillary neoplasm (1), a metastatic carcinoma (1), and an acinar cell carcinoma (1). The sensitivity, specificity, and accuracy of the diagnoses of DC in hypoechoic masses using EUS (B-mode) were 89.2%, 16.7%, and 71.4%, respectively. The sensitivity, specificity, and accuracy for the diagnosis of DC in hypovascular masses using CEH-EUS were 73.0%, 91.7%, and 77.6% in the early phase and 83.8%, 91.7%, and 85.7% in the late phase, respectively.
Conclusions: CEH-EUS for the diagnosis of DC is superior to EUS. CEH-EUS in the late phase was particularly efficacious in the diagnosis of DC.
Databáze: MEDLINE
Externí odkaz: