Clinical and Immunoinflammatory Evaluation of One-Stage Full-Mouth Ultrasonic Debridement as a Therapeutic Approach for Smokers With Generalized Aggressive Periodontitis: A Short-Term Follow-Up Study.

Autor: De Genaro Modanese D; Department of Molecular Biology, São Leopoldo Mandic Dental Institute and Research Center, Campinas, São Paulo, Brazil., Tiosso-Tamburi R; Department of Molecular Biology, São Leopoldo Mandic Dental Institute and Research Center, Campinas, São Paulo, Brazil., Furletti de Goes VF; Department of Molecular Biology, São Leopoldo Mandic Dental Institute and Research Center, Campinas, São Paulo, Brazil., de Cássia Bergamaschi C; Department of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, Brazil., Martinez EF; Department of Molecular Biology, São Leopoldo Mandic Dental Institute and Research Center, Campinas, São Paulo, Brazil., Napimoga MH; Department of Molecular Biology, São Leopoldo Mandic Dental Institute and Research Center, Campinas, São Paulo, Brazil., Peruzzo DC; Department of Molecular Biology, São Leopoldo Mandic Dental Institute and Research Center, Campinas, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of periodontology [J Periodontol] 2016 Sep; Vol. 87 (9), pp. 1012-21. Date of Electronic Publication: 2016 May 13.
DOI: 10.1902/jop.2016.150632
Abstrakt: Background: This study aims to evaluate the effect of one-stage full-mouth ultrasonic debridement (OSFMUD) on clinical and immunoinflammatory parameters in smokers with generalized aggressive periodontitis (GAgP).
Methods: Fourteen smoking and 14 non-smoking patients with GAgP were selected. After initial supragingival therapy, patients were treated by OSFMUD. Full-mouth parameters evaluated were: 1) plaque index (PI); 2) bleeding scores (BS); 3) probing depth (PD); and 4) clinical attachment level (CAL). Clinical evaluation was performed, and gingival crevicular fluid (GCF) was collected for selected sites (ss) at baseline and 1, 3, and 6 months. GCF was analyzed via enzyme-linked immunosorbent assay for: 1) receptor activator of nuclear factor-κ B ligand (RANKL); 2) osteoprotegerin (OPG); 3) interleukin (IL)-6; and 4) tumor necrosis factor (TNF)-α, whereas secreted osteoclastogenic factor of activated T-cells (SOFAT) was evaluated by Western blotting.
Results: Significant reduction (P <0.05) was observed between baseline and 6 months for: 1) PI; 2) BS; and 3) PD, with no difference between smoking and non-smoking patients (P >0.05). Regarding CAL, only non-smoking patients showed a significant decrease (P <0.05). Significant reduction (P <0.05) was observed in both groups for: 1) PIss; 2) PDss; 3) bleeding on probing; and 4) relative CAL. Smoking and non-smoking patients presented significantly decreased levels of IL-6 and TNF-α over time (P <0.05); however, no difference was observed between groups (P >0.05). RANKL was significantly different (P <0.05) only for non-smokers at 6 months, whereas OPG was not significant (P >0.05). SOFAT expression was significantly lower (P <0.05) after OSFMUD for non-smokers only.
Conclusion: Considering the clinical and immunoinflammatory parameters evaluated in this short-term follow-up study, it can be concluded that OSFMUD can be used as an alternative treatment for smokers with GAgP.
Databáze: MEDLINE
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