Brain Volumes at Term-Equivalent Age Are Associated with 2-Year Neurodevelopment in Moderate and Late Preterm Children.

Autor: Cheong JL; Neonatal Services, Royal Women's Hospital, Parkville, Australia; Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia. Electronic address: jeanie.cheong@thewomens.org.au., Thompson DK; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Florey Institute of Neuroscience and Mental Health, Melbourne, Australia., Spittle AJ; Neonatal Services, Royal Women's Hospital, Parkville, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Department of Physiotherapy, University of Melbourne, Melbourne, Australia., Potter CR; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia., Walsh JM; Neonatal Services, Royal Women's Hospital, Parkville, Australia; Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Pediatric, Infant, Perinatal Emergency Retrieval, Royal Children's Hospital, Melbourne, Australia., Burnett AC; Neonatal Services, Royal Women's Hospital, Parkville, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia., Lee KJ; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Clinical Epidemiology and Biostatistics, Murdoch Children's Research Institute, Melbourne, Australia., Chen J; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia; Department of Medicine, Monash Medical Center, Monash University, Melbourne, Australia., Beare R; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia; Department of Medicine, Monash Medical Center, Monash University, Melbourne, Australia., Matthews LG; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia., Hunt RW; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia; Department of Neonatal Medicine, Royal Children's Hospital, Melbourne, Australia., Anderson PJ; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia., Doyle LW; Neonatal Services, Royal Women's Hospital, Parkville, Australia; Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2016 Jul; Vol. 174, pp. 91-97.e1. Date of Electronic Publication: 2016 May 09.
DOI: 10.1016/j.jpeds.2016.04.002
Abstrakt: Objective: To explore the association between brain maturation, injury, and volumes at term-equivalent age with 2-year development in moderate and late preterm children.
Study Design: Moderate and late preterm infants were recruited at birth and assessed at age 2 years using the Bayley Scales of Infant and Toddler Development, Third Edition. Brain magnetic resonance imaging (MRI) was performed at term-equivalent age and qualitatively assessed for brain maturation (myelination of the posterior limb of the internal capsule and gyral folding) and injury. Brain volumes were measured using advanced segmentation techniques. The associations between brain MRI measures with developmental outcomes were explored using linear regression analyses.
Results: A total of 197 children underwent MRI and assessed using the Bayley Scales of Infant and Toddler Development, Third Edition. Larger total brain tissue volumes were associated with higher cognitive and language scores (adjusted coefficients per 10% increase in brain size; 95% CI of 3.2 [0.4, 5.6] and 5.6 [2.4, 8.8], respectively). Similar relationships were documented for white matter volumes with cognitive and language scores, multiple cerebral structures with language scores, and cerebellar volumes with motor scores. Larger cerebellar volumes were independently associated with better language and motor scores, after adjustment for other perinatal factors. There was little evidence of relationships between myelination of the posterior limb of the internal capsule, gyral folding, or injury with 2-year development.
Conclusions: Larger total brain tissue, white matter, and cerebellar volumes at term-equivalent age are associated with better neurodevelopment in moderate and late preterm children. Brain volumes may be an important marker for neurodevelopmental deficits described in moderate and late preterm children.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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