| Autor: |
Besouw MT; a Department of Pediatric Nephrology , University Hospital Ghent , Belgium., Vande Walle JG; a Department of Pediatric Nephrology , University Hospital Ghent , Belgium., Ilias MI; a Department of Pediatric Nephrology , University Hospital Ghent , Belgium.; b Department of Pediatrics , Hospital Universiti Sains Malaysia , Malaysia., Raes AM; a Department of Pediatric Nephrology , University Hospital Ghent , Belgium., Prytula AA; a Department of Pediatric Nephrology , University Hospital Ghent , Belgium., Claeys L; c Department of Pediatrics , Emmaus - Sint-Jozef Hospital , Malle , Belgium., Dehoorne JL; a Department of Pediatric Nephrology , University Hospital Ghent , Belgium. |
| Jazyk: |
angličtina |
| Zdroj: |
Acta clinica Belgica [Acta Clin Belg] 2016 Dec; Vol. 71 (6), pp. 455-457. Date of Electronic Publication: 2016 May 12. |
| DOI: |
10.1080/17843286.2016.1159383 |
| Abstrakt: |
A 12-year-old Congolese girl presented with acute renal failure, edema, hypertension, hemoptysis, hematuria, and proteinuria after a history of throat infection. Renal ultrasound showed kidneys of normal size, with increased echogenicity of the cortical parenchyma and decreased corticomedullary differentiation. Other additional investigations showed pancytopenia with decreased complement (low C3 and C4). Antinuclear antibodies were strongly positive, including anti-double stranded DNA. Renal biopsy confirmed severe grade IV lupus nephritis. She was treated with high-dose steroids, mycophenolate mofetil and hydroxychloroquine, in addition to hemodialysis. After one week of intensive treatment, diuresis recovered and dialysis could be stopped after six sessions. We describe an uncommon case of severe lupus nephritis, presenting with terminal renal failure. Since the rarity of this disease presentation, other more common diagnoses have to be considered. Once the diagnosis of lupus nephritis is established, a choice has to be made between the different induction treatment protocols. The patient's ethnic background and other supportive therapies, such as the need for dialysis, can help to make this choice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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