| Autor: |
Aleksandrova AV; BioClinicum Research and Development Complex, Moscow, Russia. a.aleksandrova@bioclinicum.com., Senyavina NV; BioClinicum Research and Development Complex, Moscow, Russia., Maltseva DV; BioClinicum Research and Development Complex, Moscow, Russia., Khutornenko AA; BioClinicum Research and Development Complex, Moscow, Russia., Sakharov DA; BioClinicum Research and Development Complex, Moscow, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Apr; Vol. 160 (6), pp. 763-6. Date of Electronic Publication: 2016 May 11. |
| DOI: |
10.1007/s10517-016-3304-7 |
| Abstrakt: |
Acetaminophen in a concentration of 5 mM increased the expression of JNK, HIF1A (hypoxiainduced factor), and CASP3, which indicated development of oxidative stress and apoptotic cell death. Acetaminophen in a concentration of 10 mM did not induce expression of HIF1A and CASP3, but reduced expression of chaperone HSP90, which attested to activation of a caspase-3-independent mechanism of cell death. The methods of preventing acetaminophen intoxication are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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