| Autor: |
Stoop RL; Department of Physics, University of Basel, Basel 4056, Switzerland. ralph.stoop@unibas.ch., Wipf M; Department of Physics, University of Basel, Basel 4056, Switzerland. mathias.wipf@gmail.com., Müller S; Department of Chemistry, University of Basel, Basel 4056, Switzerland. muelst@gmx.de., Bedner K; Laboratory for Micro- and Nanotechnology, Paul Scherrer Institute, Villigen 5232, Switzerland. KristineBedner@gmx.net., Wright IA; Department of Chemistry, University of Basel, Basel 4056, Switzerland. iain.wright@durham.ac.uk., Martin CJ; Department of Chemistry, University of Basel, Basel 4056, Switzerland. colinmtn@gmail.com., Constable EC; Department of Chemistry, University of Basel, Basel 4056, Switzerland. edwin.constable@unibas.ch., Fanget A; Department of Physics, University of Basel, Basel 4056, Switzerland. axel.fanget@unibas.ch., Schönenberger C; Department of Physics, University of Basel, Basel 4056, Switzerland. Christian.Schoenenberger@unibas.ch.; Swiss Nanoscience Institute, University of Basel, Basel 4056, Switzerland. Christian.Schoenenberger@unibas.ch., Calame M; Department of Physics, University of Basel, Basel 4056, Switzerland. michel.calame@unibas.ch.; Swiss Nanoscience Institute, University of Basel, Basel 4056, Switzerland. michel.calame@unibas.ch. |
| Abstrakt: |
Ionic gradients play a crucial role in the physiology of the human body, ranging from metabolism in cells to muscle contractions or brain activities. To monitor these ions, inexpensive, label-free chemical sensing devices are needed. Field-effect transistors (FETs) based on silicon (Si) nanowires or nanoribbons (NRs) have a great potential as future biochemical sensors as they allow for the integration in microscopic devices at low production costs. Integrating NRs in dense arrays on a single chip expands the field of applications to implantable electrodes or multifunctional chemical sensing platforms. Ideally, such a platform is capable of detecting numerous species in a complex analyte. Here, we demonstrate the basis for simultaneous sodium and fluoride ion detection with a single sensor chip consisting of arrays of gold-coated SiNR FETs. A microfluidic system with individual channels allows modifying the NR surfaces with self-assembled monolayers of two types of ion receptors sensitive to sodium and fluoride ions. The functionalization procedure results in a differential setup having active fluoride- and sodium-sensitive NRs together with bare gold control NRs on the same chip. Comparing functionalized NRs with control NRs allows the compensation of non-specific contributions from changes in the background electrolyte concentration and reveals the response to the targeted species. |
