PO-05 - Incidence of venous thromboembolism (VTE) in bile duct tumors (BDT) treated with chemotherapy in ambulatory setting.

Autor: Adrián SG; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., de Castro EM; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Olmos VP; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Martín MN; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Del Prado PM; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Mena ML; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Ramírez OR; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Lavín DC; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Arteaga JF; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain., Martín AJ; On behalf Cancer&Thrombosis Working Group, Spanish Society of MedicalOncology (SEOM); Spain.
Jazyk: angličtina
Zdroj: Thrombosis research [Thromb Res] 2016 Apr; Vol. 140 Suppl 1, pp. S178. Date of Electronic Publication: 2016 Apr 08.
DOI: 10.1016/S0049-3848(16)30138-4
Abstrakt: Introduction: The incidence of thrombosis associated with pancreatic cancer chemotherapy is high (22-36%), however the incidence in BDT is unknown.
Aim: The aim of this study is to analyze the incidence of incidental and symptomatic VTE, and its chronological pattern, in patients with BDT receiving chemotherapy in ambulatory setting.
Materials and Methods: We conducted a retrospective study to determine the incidence of VTE in patients with BDT, treated at 6 hospitals of the Cancer & Thrombosis Working Group of the Spanish Society of Medical Oncology (SEOM). 136 consecutive patients diagnosed and treated with chemotherapy, were identified between January 2008 and December 2012 and included in this analysis.
Results: Clinical characteristics in Table 1. With a median follow up of 16.6 months (range 0.4-98.2), VTE was identified in 26 patients (19.1%): 10 pulmonary embolism, 9 deep vein thrombosis and 7 visceral vein thrombosis. All VTE occurred in patients with active tumor (2 locally advanced, 24 metastatic). 46% of the events were incidentally diagnosed. 62% of the events occurred in the first 6 months after diagnosis of cancer. Eight events were identified during the diagnostic workup of the neoplasm. Only 1 patient had a VTE recurrence (superficial venous thrombosis). A non-significant trend towards lower survival (OS) in patients with VTE (median OS 20.9 months vs 13.6 months; p=0.066) was observed.
Conclusions: The incidence of VTE in patients undergoing chemotherapy for BDT in the ambulatory setting is high, but lower than that described in pancreatic cancer.
(© 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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