Spectral Domain Optical Coherence Tomography of Choroidal and Outer Retinal Layer Thickness in the Sturge Weber Syndrome.

Autor: Abdolrahimzadeh S; a Ophthalmology Unit, DAI Head/Neck, Umberto I Policlinic, University of Rome 'Sapienza' , Rome , Italy., Scavella V; b Ophthalmology Unit, Department of Sense Organs , University of Rome 'Sapienza' , Rome , Italy., Battaglia D; c Infantile Neuropsychiatry Unit, Catholic University of Sacro Cuore , Rome , Italy., Recupero SM; d Ophthalmology Unit, St. Andrea Hospital, NESMOS Department , University of Rome 'Sapienza' , Rome , Italy.
Jazyk: angličtina
Zdroj: Current eye research [Curr Eye Res] 2016 Dec; Vol. 41 (12), pp. 1614-1617. Date of Electronic Publication: 2016 May 09.
DOI: 10.3109/02713683.2015.1135962
Abstrakt: Purpose: To evaluate choroidal thickness and its effect on the outer retinal layers in patients with Sturge Weber syndrome (SWS).
Materials and Methods: Twenty eyes of 10 patients with SWS and 20 eyes of 10 healthy controls were evaluated at the ophthalmology unit of the Umberto I Policlinic, Rome from December 2015 to May 2015. Manual segmentation measurements of choroidal and retinal pigment epithelium (RPE)-photorec eptor layer (PHL) thickness were performed at the subfovea and at 500 µm intervals over 3 mm-long horizontal and vertical segments using enhanced depth spectral domain optical coherence tomography.
Results: Mean choroidal thickness of the affected (561.6 µm ± 208.8) and fellow eyes (322.0 µm ± 56.6) of patients with SWS was significantly higher with respect to controls (266.5 µm ± 48.5 µm), p = 0.001 and p = 0.017, respectively. Mean RPE-PHL thickness was significantly lower in both the affected and fellow eyes of patients with respect to controls (p = 0.039 and p = 0.025, respectively).
Conclusions: The choroid is thickened in patients with SWS, but the RPE-PHL is thinner. Choroidal thickening may lead to functional impairment causing disruption in the fine equilibrium between the choroid and retina and consequent outer retinal layer thinning.
Databáze: MEDLINE
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