[Extemporaneous withdrawal with a mini-spike filter: A low infection risk technique for drawing up bevacizumab for intravitreal injection].

Autor:	Le Rouic JF; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France. Electronic address: jflerouic@gmail.com., Breger D; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France., Peronnet P; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France., Hermouet-Leclair E; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France., Alphandari A; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France., Pousset-Decré C; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France., Badat I; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France., Becquet F; Clinique Sourdille, 3, place Anatole-France, 44000 Nantes, France.
Jazyk:	francouzština
Zdroj:	Journal francais d'ophtalmologie [J Fr Ophtalmol] 2016 May; Vol. 39 (5), pp. 415-20. Date of Electronic Publication: 2016 May 05.
DOI:	10.1016/j.jfo.2016.01.007
Abstrakt:	Purpose: To describe a technique for extemporaneously drawing up bevacizumab for intravitreal injection (IVT) and report the rate of post-injection endophthtalmitis. Patients and Methods: Retrospective monocentric analysis (January 2010-December 2014) of all IVT of bevacizumab drawn up with the following technique: in the operating room (class ISO 7) through a mini-spike with an integrated bacteria retentive air filter. The surgeon was wearing sterile gloves and a mask. The assisting nurse wore a mask. The bevacizumab vial was discarded at the end of each session. Results: Six thousand two hundred and thirty-six bevacizumab injections were performed. One case of endophthalmitis was noted (0.016%). During the same period, 4 cases of endophthalmitis were found after IVT of other drugs (4/32,992; 0.012%. P=0.8). Conclusion: Intravitreal injection of bevacizumab after extemporaneous withdrawal through a mini-spike filter is a simple and safe technique. The risk of postoperative endophthalmitis is very low. This simple technique facilitates access to compounded bevacizumab. (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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