High-performance web services for querying gene and variant annotation.

Autor: Xin J; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Mark A; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.; Current address: Avera Cancer Institute, 11099 North Torrey Pines Road, La Jolla, CA, 92037, USA., Afrasiabi C; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Tsueng G; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Juchler M; Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA., Gopal N; Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA., Stupp GS; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Putman TE; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Ainscough BJ; McDonnell Genome Institute, Washington University School of Medicine, 4444 Forest Park Ave, St. Louis, MO, 63108, USA., Griffith OL; McDonnell Genome Institute, Washington University School of Medicine, 4444 Forest Park Ave, St. Louis, MO, 63108, USA., Torkamani A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.; The Scripps Translational Science Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Whetzel PL; Center for Research in Biological Systems, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA., Mungall CJ; Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA, 94720, USA., Mooney SD; Department of Biomedical Informatics and Medical Education, The University of Washington, Box SLU-BIME 358047, Seattle, WA, 98195, USA., Su AI; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. asu@scripps.edu.; The Scripps Translational Science Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. asu@scripps.edu., Wu C; Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. cwu@scripps.edu.
Jazyk: angličtina
Zdroj: Genome biology [Genome Biol] 2016 May 06; Vol. 17 (1), pp. 91. Date of Electronic Publication: 2016 May 06.
DOI: 10.1186/s13059-016-0953-9
Abstrakt: Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://mygene.info and http://myvariant.info . Both are offered free of charge to the research community.
Databáze: MEDLINE
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