Integrated Study of Globally Expressed microRNAs in IL-1β-stimulated Human Osteoarthritis Chondrocytes and Osteoarthritis Relevant Genes: A Microarray and Bioinformatics Analysis.

Autor: Rasheed Z; a Department of Medical Biochemistry , College of Medicine, Qassim University , Buraidah , KSA., Al-Shobaili HA; b Department of Dermatology , College of Medicine, Qassim University , Buraidah , KSA., Rasheed N; a Department of Medical Biochemistry , College of Medicine, Qassim University , Buraidah , KSA., Al Salloom AA; c Department of Pathology , College of Medicine, Qassim University , Buraidah , KSA., Al-Shaya O; d Department of Orthopedics , King Fahd Medical City , Riyadh , KSA., Mahmood A; e Stem Cell Unit , Department of Anatomy, College of Medicine, King Saud University , Riyadh , KSA., Alajez NM; e Stem Cell Unit , Department of Anatomy, College of Medicine, King Saud University , Riyadh , KSA., Alghamdi AS; d Department of Orthopedics , King Fahd Medical City , Riyadh , KSA., Mehana el-SE; c Department of Pathology , College of Medicine, Qassim University , Buraidah , KSA.
Jazyk: angličtina
Zdroj: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2016 Jul 02; Vol. 35 (7), pp. 335-55. Date of Electronic Publication: 2016 May 06.
DOI: 10.1080/15257770.2016.1163380
Abstrakt: This study was undertaken to identify and characterize the globally expressed microRNAs (miRNAs) involved in interleukin-1β (IL-1β)-induced joint damage and to predict whether miRNAs can regulate the catabolic effects in osteoarthritis (OA) chondrocytes. Out of 1347 miRNAs analyzed by microarrays in IL-1β-stimulated OA chondrocytes, 35 miRNAs were down-regulated, 1 miRNA was up-regulated, and the expression of 1311 miRNAs remained unchanged. Bioinformatics analysis showed the key inflammatory mediators and key molecular pathways are targeted by differentially expressed miRNAs. Novel miRNAs identified could have important diagnostic and therapeutic potentials in the development of novel therapeutic strategies for pain managements in OA.
Databáze: MEDLINE
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