Association between selected dietary scores and the risk of urothelial cell carcinoma: A prospective cohort study.

Autor: Dugué PA; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia., Hodge AM; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia., Brinkman MT; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia., Bassett JK; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia., Shivappa N; Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.; Connecting Health Innovations LLC, Columbia, SC., Hebert JR; Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.; Connecting Health Innovations LLC, Columbia, SC., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia., English DR; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia., Milne RL; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia., Giles GG; Cancer Council Victoria, Cancer Epidemiology Centre, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2016 Sep 15; Vol. 139 (6), pp. 1251-60. Date of Electronic Publication: 2016 May 19.
DOI: 10.1002/ijc.30175
Abstrakt: Studies investigating the association of food and nutrient consumption with the risk of urothelial cell carcinoma (UCC) have produced mixed results. We used three common dietary scores, the Mediterranean Diet Score (MDS), the Alternate Healthy Eating Index 2010 (AHEI-2010) and the Dietary Inflammatory Index (DII) to assess the evidence of an association between diet and the risk of UCC. Over a median follow-up time of 21.3 years, 379 incident UCC cases were diagnosed. Dietary scores were calculated using data from a 121-item food frequency questionnaire administered at baseline. We used Cox models to compute hazard ratios (HR) for the association between dietary scores (per one standard deviation) and UCC risk. In order to reflect overall adherence to a healthy diet, a metascore was constructed by summing the quintiles of each of the three scores. None of the dietary scores was associated with the risk of UCC overall. A healthier diet was found to be inversely associated with the risk of invasive (MDS: HR = 0.86, 95% CI: 0.74-1.00, metascore: HR = 0.84, 95% CI: 0.71-0.98), but not superficial disease (heterogeneity between subtypes p = 0.04 and p = 0.03, respectively). Results were consistent but weaker for the DII and the AHEI-2010. We found some evidence of effect modification by smoking, in particular for the metascore (Current: HR = 0.77, 95% CI: 0.58-1.01, Former: HR = 0.77, 95% CI: 0.64-0.92, Never: HR = 1.01, 95% CI: 0.81-1.26, p for heterogeneity = 0.05). A healthy diet may be protective against the risk of invasive, but not superficial, UCC. Promoting healthy dietary habits may help lower the risk of invasive UCC, especially for current and former smokers.
(© 2016 UICC.)
Databáze: MEDLINE
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