The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis.

Autor:	de Freitas EO; The Jenner Institute, University of Oxford , Oxford , UK., Leoratti FM; The Jenner Institute, University of Oxford , Oxford , UK., Freire-de-Lima CG; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil., Morrot A; Laboratorio de Biologia do Sistema Imune, Departmento de Imunologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil., Feijó DF; Laboratório Integrado de Microbiologia e Imunoregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) , Salvador , Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2016 Apr 22; Vol. 7, pp. 153. Date of Electronic Publication: 2016 Apr 22 (Print Publication: 2016).
DOI:	10.3389/fimmu.2016.00153
Abstrakt:	Leishmania is a genus of protozoan parasites that give rise to a range of diseases called Leishmaniasis that affects annually an estimated 1.3 million people from 88 countries. Leishmania donovani and Leishmania (L.) infantum chagasi are responsible to cause the visceral leishmaniasis. The parasite can use assorted strategies to interfere with the host homeostasis to establish persistent infections that without treatment can be lethal. In this review, we highlight the mechanisms involved in the parasite subversion of the host protective immune response and how alterations of host tissue physiology and vascular remodeling during VL could affect the organ-specific immunity against Leishmania parasites.
Databáze:	MEDLINE
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