Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome.

Autor:	Spahiu L; Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo., Jashari H; Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo; Department of Public Health and Clinical Medicine, Umeå University, Sweden., Mulliqi-Kotori V; Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo., Elezi-Rugova B; Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo., Merovci B; Pediatric Clinic, University Clinical Center of Kosovo, Pristina, Republic of Kosovo.
Jazyk:	angličtina
Zdroj:	Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH [Acta Inform Med] 2016 Apr; Vol. 24 (2), pp. 143-5. Date of Electronic Publication: 2016 Mar 26.
DOI:	10.5455/aim.2016.24.143-145
Abstrakt:	Introduction: Hypothyroidism has been reported to affect renal function and structure. However, the association of hypothyroidism with distal renal tubular acidosis (dRTA) is rarely reported in children. Case Presentation: We present a 6-year-boy with Down syndrome admitted in our department due to vomiting, weakness, polyuria, polydipsia, irritability and weight loss in the last few weeks. Investigations revealed features of hypokalemia, metabolic acidosis and alkaline urine consistent with dTRA. Abdominal ultrasound found nephrocalcinosis. In addition, Antithyroid peroxidase antibodies were positive, suggesting an autoimmune background for the pathogenesis of the tubular dysfunction. Treatment for dRTA and hypothyroidism was started and symptomatic improve was noticed. Conclusion: dRTA should be excluded in children with autoimmune disorders who develop weakness, polyuria, polydipsia or growth failure. Early diagnosis would reduce long-term complications.
Databáze:	MEDLINE
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