Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period.

Autor:	Ribeiro SM; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Brazil., Moya AM; Ribeirão Preto Medical School, University of São Paulo, Brazil., Braga CB; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Brazil., Domenici FA; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Brazil., Feitosa MR; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil., Feres O; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil., Rocha JJ; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Brazil., Cunha SF; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2016; Vol. 31 Suppl 1, pp. 24-8.
DOI:	10.1590/S0102-86502016001300006
Abstrakt:	Purpose: This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. Methods: The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritional status, serum calprotectin and plasma Cu and Zn concentrations. Mann-Whitney U-test was performed between-group comparisons and Spearman correlation test for correlations between the variables. Results: Individuals in the Cancer Group presented significantly lower BMI, fat mass, plasma hemoglobin, total protein and albumin as compared with the Control Group. Serum calprotectin[70.1 ng/mL (CI95% 55.8-84.5) vs.53.3 ng/mL (40.3-66.4), p=0.05], plasma Cu concentrations [120 µg/dL(CI95% 114-126) vs. 106 µg/dL(CI95% 98-114), p<0.01] and the Cu/Zn ratio [1.59 (CI95% 1.48-1.71)vs. 1.35 (CI95% 1.23-1.46), p=0.01]were higher in patients with colorectal cancer than in controls. Additionally, the Cancer Group showed negative correlations between the Cu/Zn ratio and Zn intake, hemoglobin, serum albumin, and positive correlation between the Cu/Zn ratio and serum calprotectin. Conclusion: These results indicate that an increased plasma Cu/Zn ratio and serum calprotectin, and decreased protein values may be a result of the systemic inflammatory response to the tumor process.
Databáze:	MEDLINE
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