Epithelial expression of cytokeratins 15 and 19 in vitiligo.

Autor: Saleh FY; Department of Dermatology, STDs and Andrology, Faculty of Medicine, Minia University, Minia, Egypt., Awad SS; Department of Dermatology, STDs and Andrology, Faculty of Medicine, Minia University, Minia, Egypt., Nasif GA; Department of Dermatology, STDs and Andrology, Faculty of Medicine, Minia University, Minia, Egypt., Halim C; Department of Dermatology, STDs and Andrology, Faculty of Medicine, Minia University, Minia, Egypt.
Jazyk: angličtina
Zdroj: Journal of cosmetic dermatology [J Cosmet Dermatol] 2016 Dec; Vol. 15 (4), pp. 312-317. Date of Electronic Publication: 2016 May 02.
DOI: 10.1111/jocd.12223
Abstrakt: Background: Cytokeratins (CK) belong to the family of intermediate filament proteins, and among them specific epithelial keratins are considered markers for stem cells activation.
Objectives: This study aims to investigate the expression of CK15 and CK19 as possible stem cell markers in vitiligo during phototherapy.
Methods: The study was conducted on vitiligo patients receiving narrow-band ultraviolet therapy. Immunohistochemical staining for CK15 and CK19 was carried out, and clinical follow-up continued for 4 weeks.
Results: Of 28 patients, CK15 expression was demonstrated in 17 cases (61%) while CK19 expression was demonstrated in 11 cases (39%). Cells expressing positive staining were demonstrated in follicular and interfollicular epithelium. Expression was clearly demonstrated in patients younger than 20 years old, with shorter disease duration, with disease stability, and with normally pigmented hairs. Expression of cytokeratins was significantly correlated to improvement of vitiligo lesions.
Conclusion: CK15 and CK19 are expressed in vitiligo during UV repigmentation in the follicular and interfollicular epithelium. This expression of cytokeratins was significantly correlated to improvement and can be considered valuable tool to monitor stem cells stimulation for the sake of the repigmentation process in vitiligo.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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