Synthesis, characterization, theoretical prediction of activities and evaluation of biological activities of some sulfacetamide based hydroxytriazenes.

Autor: Agarwal S; Co-Ordination Chemistry Laboratory, Department of Chemistry, Mohan Lal Sukhadia University, Udaipur (Rajasthan), India., Baroliya PK; Co-Ordination Chemistry Laboratory, Department of Chemistry, Mohan Lal Sukhadia University, Udaipur (Rajasthan), India., Bhargava A; Department of Pharmacology, B.N. Institute of Pharmaceutical Sciences, Udaipur (Rajasthan), India., Tripathi IP; Faculty of Science & Environment, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidhyalaya, Chitrakoot (M.P.), India., Goswami AK; Co-Ordination Chemistry Laboratory, Department of Chemistry, Mohan Lal Sukhadia University, Udaipur (Rajasthan), India.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Jun 15; Vol. 26 (12), pp. 2870-2873. Date of Electronic Publication: 2016 Apr 19.
DOI: 10.1016/j.bmcl.2016.04.051
Abstrakt: Six new N [(4-aminophenyl)sulfonyl]acetamide based hydroxytriazenes have been synthesized and characterized using elemental analysis, IR, 1H NMR, 13C NMR and MASS spectral analysis. Further, their theoretical predictions for probable activities have been taken using PASS (Prediction of Activity Spectra for Substance). Although a number of activities have been predicted but specifically anti-inflammatory, antiradical, anti-diabetic activities have been experimentally validated which proves that theoretical predictions agree with the experimental results. The object of the Letter is to establish Computer Aided Drug Design (CADD) using our compounds.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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