Embryonic stem cells markers Oct4 and Nanog correlate with perineural invasion in human salivary gland mucoepidermoid carcinoma.

Autor: Destro Rodrigues MF; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Sedassari BT; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Esteves CM; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., de Andrade NP; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Altemani A; Department of Pathology, School of Medicine, State University of Campinas, Campinas, Brazil., de Sousa SC; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil., Nunes FD; Department of Oral Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2017 Feb; Vol. 46 (2), pp. 112-120. Date of Electronic Publication: 2016 May 01.
DOI: 10.1111/jop.12449
Abstrakt: Background: Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy and is successfully treated by surgery and radiation. However, some patients have recurrent tumours and in these cases, few treatments options are available. Cancer stem cells (CSC) have been observed and isolated from different solid tumours based on the expression of stem cell markers. These cells are associated with tumour initiation, progression as well as treatment resistance. In this study, the expression of stem cell markers CD44, Bmi1, Oct4 and Nanog was evaluated in non-neoplastic salivary tissue and in MEC.
Methods: Twenty-eight samples of MEC and their corresponding non-neoplastic salivary tissue were examined by immunohistochemistry and the stem cell markers expression was correlated with histological and clinical parameters.
Results: CD44 was expressed in the membrane of serous and mucous acini as well as in the ductal cells in normal gland tissue. Bmi1, Oct4 and Nanog were mainly expressed in ductal structures. In MEC, CD44 and Bmi1 showed strong expression in all types of neoplastic cells and both markers revealed intense expression in tumour invasive front. Oct4 and Nanog protein expression was associated with desmoplasia and perineural invasion. Only Oct4 positive tumours were associated with dissociative growth pattern and committed margins.
Conclusion: The stem cell markers CD44, Bmi1, Oct4 and Nanog are frequently expressed in MEC in relation to normal salivary gland and Oct4 and Nanog expression may contribute to aggressiveness and worst prognosis in MEC patients.
(© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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