Serum of 25-Hydroxyvitamin D and Intact Parathyroid Hormone Levels in Postmenopausal Women with Hip and Upper Limb Fractures.

Autor: Lv JT; Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China., Zhang YY; Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China., Tian SQ; Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China., Sun K; Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266003, Shandong Province, China.
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2016 May; Vol. 64 (5), pp. 1068-72. Date of Electronic Publication: 2016 Apr 30.
DOI: 10.1111/jgs.14082
Abstrakt: Objectives: To assess the serum of 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (iPTH) levels in postmenopausal women from northern China with hip and upper limb fractures.
Design: Case-control.
Setting: Affiliated Hospital of Qingdao University.
Participants: Postmenopausal women diagnosed with hip fracture (n = 335) and matched controls without fracture (n = 335).
Measurements: Between 2011 and 2013, fasting venous samples were analyzed for 25(OH)D, iPTH, alkaline phosphatase (ALP), calcium, and phosphorus. All women completed a standardized questionnaire designed to document putative risk factors for fractures.
Results: Eight percent of participants had vitamin D deficiency, and 66.0% had secondary hyperparathyroidism. Serum 25(OH)D levels were significantly (P < .001) lower in women with hip fracture than in controls. Multivariate logistic regression analysis adjusted for common risk factors showed that serum 25(OH)D of 20 ng/mL or less was an independent indicator of hip fracture (odds ratio (OR) = 2.98, 95% confidence interval (CI) = 2.11-4.20) and concomitant upper limb fracture in those with existing hip fractures (OR = 4.77, 95% CI = 1.60-10.12). The area under the receiver operating characteristic curve of 25(OH)D was 0.77 (95% CI = 0.68-0.84) for hip fracture and 0.80 (95% CI = 0.72-0.89) for hip and upper limb fractures.
Conclusion: Vitamin D insufficiency and secondary hyperparathyroidism were a common problem in postmenopausal women who presented with concomitant hip and upper limb fractures, suggesting that they might contribute to the pathophysiology of fractures in postmenopausal women.
(© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.)
Databáze: MEDLINE
Externí odkaz: