Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations.

Autor:	Ivanova SA; Mental Health Research Institute, Tomsk, Russian Federation; National Research Tomsk Polytechnic University, Tomsk, Russian Federation., Loonen AJ; Department of Pharmacy, University of Groningen, Groningen, The Netherlands; GGZ Westelijk Noord-Brabant, Bergen op Zoom, The Netherlands., Bakker PR; Psychiatric Centre GGZ Centraal, Amersfoort, The Netherlands; Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands., Freidin MB; Research Institute for Medical Genetics, Tomsk, Russian Federation., Ter Woerds NJ; Department of Pharmacy, University of Groningen, Groningen, The Netherlands., Al Hadithy AF; Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Parnassia Group, Pharmacy Haaglanden, The Hague, The Netherlands., Semke AV; Mental Health Research Institute, Tomsk, Russian Federation., Fedorenko OY; Mental Health Research Institute, Tomsk, Russian Federation; National Research Tomsk Polytechnic University, Tomsk, Russian Federation., Brouwers JR; Department of Pharmacy, University of Groningen, Groningen, The Netherlands., Bokhan NA; Mental Health Research Institute, Tomsk, Russian Federation; National Research Tomsk State University, Tomsk, Russian Federation., van Os J; Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, London, UK., van Harten PN; Psychiatric Centre GGZ Centraal, Amersfoort, The Netherlands; Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University Medical Centre, Maastricht, The Netherlands., Wilffert B; Department of Pharmacy, University of Groningen, Groningen, The Netherlands; Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, Groningen, The Netherlands.
Jazyk:	angličtina
Zdroj:	SAGE open medicine [SAGE Open Med] 2016 Apr 11; Vol. 4, pp. 2050312116643673. Date of Electronic Publication: 2016 Apr 11 (Print Publication: 2016).
DOI:	10.1177/2050312116643673
Abstrakt:	Objectives: An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors and tardive dyskinesia. Methods: We assessed tardive dyskinesia in Caucasian psychiatric inpatients from Siberia (N = 431) and a long-stay population from the Netherlands (N = 168). These patients were genotyped for 43 tag single nucleotide polymorphisms in five neurotransmitter receptor genes, and the results for the two populations were compared. Results: Several significant associations with tardive dyskinesia were identified, but only GRIN2A (rs1345423) was found in both patient populations. This lack of agreement was probably due to the small effect size of the associations, the multiple testing and the small sample size of the Dutch patient population. After reviewing the literature, we propose that the constitutive stimulatory activity of serotonergic type 2 receptors may be relevant. Conclusions: Inactivity of the serotonergic, type 2C receptor or blockade of these receptors by atypical antipsychotic drugs may decrease the vulnerability to develop tardive dyskinesia.
Databáze:	MEDLINE
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