α-Terpineol Induces Gastric Retention of Liquids by Inhibiting Vagal Parasympathetic Pathways in Rats.
| Autor: | da Silva MT; Department of Physical Education, Federal University of Piaui, Teresina, PI, Brazil., Marques RB; Center for Research on Medicinal Plants, Federal University of Piaui, Teresina, PI, Brazil., Batista-Lima FJ; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil., Soares MA; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil., Dos Santos AA; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil., Magalhães PJ; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil., de Assis Oliveira F; Center for Research on Medicinal Plants, Federal University of Piaui, Teresina, PI, Brazil., de Castro Almeida FR; Center for Research on Medicinal Plants, Federal University of Piaui, Teresina, PI, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Planta medica [Planta Med] 2016 Oct; Vol. 82 (15), pp. 1329-1334. Date of Electronic Publication: 2016 Apr 28. |
| DOI: | 10.1055/s-0042-104657 |
| Abstrakt: | α -Terpineol is a monoterpene with smooth muscle relaxant properties. In this study, its effects on the gastric emptying rate of awake rats were evaluated with emphasis on the mode by which it induces gastrointestinal actions. Administered by gavage, α -terpineol (50 mg/kg) delayed gastric emptying of a liquid test meal at 10 min postprandial. Hexamethonium or guanethidine did not interfere with the retarding effect induced by α -terpineol, but atropine and L-N G -nitroarginine methyl ester abolished it. In vagotomized rats, α -terpineol did not delay gastric emptying. In isolated strips of gastric fundus, concentration-effect curves in response to carbamylcholine were higher in magnitude after treatment with the monoterpene. α -Terpineol (1 to 2000 µM) relaxed sustained contractions induced by carbamylcholine or a high K + concentration in a concentration-dependent manner. This relaxing effect was not affected by the presence of L-N G -nitroarginine methyl ester, 1 H-[1, 2, 4]oxadiazolo[4,3-a]quinoxalin-1-one, tetraethylammonium, or atropine. Smooth muscle contractions induced by electrical field stimulation were inhibited by α -terpineol. In conclusion, α -terpineol induced gastric retention in awake rats through mechanisms that depended on intact vagal innervation to the stomach, which involved cholinergic/nitrergic signalling. Such a retarding effect induced by α -terpineol appears not to result from a direct action of the monoterpene on gastric smooth muscle cells. (Georg Thieme Verlag KG Stuttgart · New York.) |
| Databáze: | MEDLINE |
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