Vascular malformations of central nervous system: A series from tertiary care hospital in South India.

Autor: Karri SB; Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Uppin MS; Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Rajesh A; Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Ashish K; Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Bhattacharjee S; Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Rani YJ; Department of Radiology and Imageology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Sahu BP; Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Saradhi MV; Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Purohit AK; Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India., Challa S; Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Jazyk: angličtina
Zdroj: Journal of neurosciences in rural practice [J Neurosci Rural Pract] 2016 Apr-Jun; Vol. 7 (2), pp. 262-8.
DOI: 10.4103/0976-3147.176196
Abstrakt: Aims and Objectives: To describe clinicopathological features of surgically resected vascular malformations (VMs) of central nervous system (CNS).
Materials and Methods: Histologically diagnosed cases of VMs of CNS during April 2010-April 2014 were included. Demographic data, clinical and radiological features were obtained. Hematoxylin and eosin slides were reviewed along with Verhoeff-Van Gieson (VVG), Masson's trichrome, periodic acid-Schiff, and Perls' stains. Morphologically, cavernomas and arteriovenous malformations (AVMs) were distinguished on the basis of vessel wall features on VVG and intervening glial parenchyma.
Results: Fifty cases were diagnosed as VMs of CNS with an age range of 14-62 years. These included 36 cavernomas, 12 AVMs, 2 mixed capillary-cavernous angiomas. Most of the cavernoma patients (15/36) presented with seizures, whereas AVM patients (8/12) had a headache as the dominant symptom. Twenty-nine patients were reliably diagnosed on radiological features. Microscopic evidence of hemorrhage was seen in 24/36 cavernomas and 6/12 AVMs, as opposed to radiologic evidence of 10 and 4, respectively. Reactive gliosis was seen in 16 cavernomas.
Conclusions: Histological features are important for classifying the VMs of CNS as there are no specific clinical and radiological features. Type of VM has a bearing on management, prognosis, and risk of hemorrhage.
Databáze: MEDLINE
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