Pulsatile Load Components, Resistive Load and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis (MESA).
Autor: | Zamani P; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine. Philadelphia, Pennsylvania. Electronic address: pzamani@upenn.edu., Lilly SM; Division of Cardiovascular Medicine, Ohio State University Heart and Vascular Center, Columbus, Ohio., Segers P; Biofluid, Tissue, and Solid Mechanics for Medical Applications, Ibitech, iMinds Medical IT, Ghent University, Ghent, Belgium., Jacobs DR Jr; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minnesota., Bluemke DA; National Institutes of Health, Bethesda, Maryland; Departments of Radiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Duprez DA; Division of Cardiology, School of Medicine, University of Minnesota. Minneapolis, Minnesota., Chirinos JA; Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Perelman School of Medicine. Philadelphia, Pennsylvania. |
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Jazyk: | angličtina |
Zdroj: | Journal of cardiac failure [J Card Fail] 2016 Dec; Vol. 22 (12), pp. 988-995. Date of Electronic Publication: 2016 Apr 19. |
DOI: | 10.1016/j.cardfail.2016.04.011 |
Abstrakt: | Background: Left ventricular (LV) afterload is composed of systemic vascular resistance (SVR) and components of pulsatile load, including total arterial compliance (TAC), and reflection magnitude (RM). RM, which affects the LV systolic loading sequence, has been shown to strongly predict HF. Effective arterial elastance (E Methods: We studied 4345 MESA participants who underwent radial arterial tonometry and cardiac output (CO) measurements with the use of cardiac MRI. RM was computed as the ratio of the backward (P Results: During 10.3 years of follow-up, 91 definite HF events occurred. SVR (P = .74), TAC (P = .81), and E Conclusions: RM is an important independent predictor of HF risk, whereas TAC, SVR, and E (Copyright © 2016 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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