Neocortical neuronal morphology in the Siberian Tiger (Panthera tigris altaica) and the clouded leopard (Neofelis nebulosa).

Autor: Johnson CB; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903., Schall M; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903., Tennison ME; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903., Garcia ME; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903., Shea-Shumsky NB; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903., Raghanti MA; Department of Anthropology and School of Biomedical Sciences, Kent State University, Kent, Ohio, 44242., Lewandowski AH; Cleveland Metroparks Zoo, Cleveland, Ohio, 44109., Bertelsen MF; Center for Zoo and Wild Animal Health, Copenhagen Zoo, 2000, Fredericksberg, Denmark., Waller LC; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903., Walsh T; Smithsonian National Zoological Park, Washington, DC, 20008., Roberts JF; Thompson Bishop Sparks State Diagnostic Laboratory, Alabama Department of Agriculture and Industries, Auburn, Alabama, 36849., Hof PR; Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, 10029., Sherwood CC; Department of Anthropology, The George Washington University, Washington, DC, 20052., Manger PR; School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2000, South Africa., Jacobs B; Laboratory of Quantitative Neuromorphology, Neuroscience Program, Colorado College, Colorado Springs, Colorado, 80903. BJacobs@ColoradoCollege.edu.
Jazyk: angličtina
Zdroj: The Journal of comparative neurology [J Comp Neurol] 2016 Dec 01; Vol. 524 (17), pp. 3641-3665. Date of Electronic Publication: 2016 May 17.
DOI: 10.1002/cne.24022
Abstrakt: Despite extensive investigations of the neocortex in the domestic cat, little is known about neuronal morphology in larger felids. To this end, the present study characterized and quantified the somatodendritic morphology of neocortical neurons in prefrontal, motor, and visual cortices of the Siberian tiger (Panthera tigris altaica) and clouded leopard (Neofelis nebulosa). After neurons were stained with a modified Golgi technique (N = 194), dendritic branching and spine distributions were analyzed using computer-assisted morphometry. Qualitatively, aspiny and spiny neurons in both species appeared morphologically similar to those observed in the domestic cat. Although the morphology of spiny neurons was diverse, with the presence of extraverted, inverted, horizontal, and multiapical pyramidal neurons, the most common variant was the typical pyramidal neuron. Gigantopyramidal neurons in the motor cortex were extremely large, confirming the observation of Brodmann ([1909] Vergleichende Lokalisationlehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues. Leipzig, Germany: J.A. Barth), who found large somata for these neurons in carnivores in general, and felids in particular. Quantitatively, a MARSplines analysis of dendritic measures differentiated typical pyramidal neurons between the Siberian tiger and the clouded leopard with 93% accuracy. In general, the dendrites of typical pyramidal neurons were more complex in the tiger than in the leopards. Moreover, dendritic measures in tiger pyramidal neurons were disproportionally large relative to body/brain size insofar as they were nearly as extensive as those observed in much larger mammals (e.g., African elephant). Comparison of neuronal morphology in a more diverse collection of larger felids may elucidate the comparative context for the relatively large size of the pyramidal neurons observed in the present study. J. Comp. Neurol. 524:3641-3665, 2016. © 2016 Wiley Periodicals, Inc.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: