Iliac artery myointimal hyperplasia in rabbits submitted to angioplasty and treated with Moringa oleifera.

Autor:	Rolim JC; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil., Nogueira MR; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil., Lima PR; Universidade Federal de Alagoas, Maceió, AL, Brasil., Bandeira FC; Universidade Federal de Alagoas, Maceió, AL, Brasil., Pordeus MA; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil., Castro AA; Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brasil., Pitta GB; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil., Diniz Mde F; Universidade Federal da Paraíba, João Pessoa, PB, Brasil., Pereira AH; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Jazyk:	English; Portuguese
Zdroj:	Revista do Colegio Brasileiro de Cirurgioes [Rev Col Bras Cir] 2016 Feb; Vol. 43 (1), pp. 28-34.
DOI:	10.1590/0100-69912016001007
Abstrakt:	Objective: to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves. Methods: we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05. Results: there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty. Conclusion: there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.
Databáze:	MEDLINE
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