Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea.

Autor: Ferrandez B; Department of Ophthalmology, IIS-Aragon, Miguel Servet University Hospital, Isabel la Catolica 1-3, 50009, Zaragoza, Spain., Ferreras A; Department of Ophthalmology, IIS-Aragon, Miguel Servet University Hospital, Isabel la Catolica 1-3, 50009, Zaragoza, Spain. aferreras@msn.com.; University of Zaragoza, Zaragoza, Spain. aferreras@msn.com., Calvo P; Department of Ophthalmology, IIS-Aragon, Miguel Servet University Hospital, Isabel la Catolica 1-3, 50009, Zaragoza, Spain.; University of Zaragoza, Zaragoza, Spain., Abadia B; Department of Ophthalmology, IIS-Aragon, Miguel Servet University Hospital, Isabel la Catolica 1-3, 50009, Zaragoza, Spain., Marin JM; University of Zaragoza, Zaragoza, Spain.; Department of Pneumology, Miguel Servet University Hospital, Zaragoza, Spain., Pajarin AB; Centro de Salud Seminario, Zaragoza, Spain.
Jazyk: angličtina
Zdroj: BMC ophthalmology [BMC Ophthalmol] 2016 Apr 18; Vol. 16, pp. 40. Date of Electronic Publication: 2016 Apr 18.
DOI: 10.1186/s12886-016-0216-2
Abstrakt: Background: The effect of obstructive sleep apnea (OSA) syndrome in the peripapillary retinal nerve fiber layer (RNFL) thicknesses remains unclear. The purpose of this study was to assess RNFL measurements acquired using scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in patients with OSA.
Methods: The sample of this cross-sectional study included 40 OSA patients and 45 age-matched controls, consecutively and prospectively selected. All participants underwent at least one reliable standard automated perimetry (SAP) test, while RNFL measurements were obtained using the SLP and OCT. The OSA group was divided into 3 sub-groups based on the apnea/hypopnea index (AHI): mild, moderate, or severe OSA. SAP, SLP, and OCT outcomes were compared between the control and OSA groups. The relationship between AHI and RNFL parameters was also evaluated.
Results: Age was not different between both groups. Mean deviation of SAP was -0.47 ± 0.9 dB and -1.43 ± 2.3 dB in the control and OSA groups, respectively (p = 0.01). RNFL thickness measured with OCT was similar between groups. OSA patients showed increased nerve fiber indicator (NFI; 20.9 ± 7.9 versus 16.42 ± 7.82; p = 0.01) and decreased superior average (59.74 ± 10.35 versus 63.73 ± 6.58; p = 0.03) obtained with SLP compared with healthy individuals. In the total sample, NFI and AHI were moderately correlated (r = 0.358; p = 0.001). In severe OSA subjects (n = 22), NFI and AHI had a Spearman correlation coefficient of 0.44 (p = 0.04).
Conclusion: RNFL thickness measured with OCT did not differ significantly between groups. Severe OSA was related to a reduction of the RNFL thickness assessed by SLP.
Databáze: MEDLINE
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